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Bredesen Center for Interdisciplinary Research and Graduate Education (UTK-ORNL)

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Bredesen Center Faculty

Adam Guss

gussam@ornl.gov

Adam GussDr. Guss is a Genetic and Metabolic Engineer at Oak Ridge National Laboratory and Joint Faculty Assistant Professor in the Bredesen Center at the University of Tennessee at Knoxville. Dr. Adam Guss received his Ph.D. from the University of Illinois at Urbana Ė Champaign in the Department of Microbiology studying the electron transport pathways used by members of the Archaea to produce methane. He was a Microbial Sciences Initiative Postdoctoral Fellow at Harvard University studying the phylogenetic and metabolic diversity of non-cultured and rarely cultured bacteria present in the lungs of cystic fibrosis patients. He then worked in Lee Lyndís research group at Dartmouth College as a Postdoctoral Researcher and Research Scientist as a member of the BioEnergy Science Center (BESC). His work involved improving genetic tools and metabolic engineering of Clostidium thermocellum for production of biofuels from cellulosic biomass. Dr. Gussí research utilizes genetics and synthetic biology to engineer microbes to convert lignocellulosic plant biomass and other waste into liquid fuels and other value-added products. Within BESC, his major research focus is the metabolic engineering of thermophilic, cellulose-degrading bacteria such as C. thermocellum and members of the Caldicellulosiruptor genus for production of liquid fuels.

Research Areas

  • Metabolic engineering
  • Synthetic biology
  • Biofuels and bioproducts
  • Metabolic diversity

Selected Publications

Cha M, Chung D, Elkins JG, Guss AM, Westpheling J. Metabolic engineering of Caldicellulosiruptor bescii yields increased hydrogen production from lignocellulosic biomass. Biotechnol Biofuels. 2013 Jun 3;6(1):85.

van der Veen D, Lo J, Brown SD, Johnson CM, Tschaplinski TJ, Martin M, Engle NL, van den Berg RA, Argyros AD, Caiazza NC, Guss AM, Lynd LR. Characterization of Clostridium thermocellum strains with disrupted fermentation end-product pathways. J Ind Microbiol Biotechnol. 2013 Jul;40(7):725-34.

Currie DH, Herring CD, Guss AM, Olson DG, Hogsett DA, Lynd LR. Functional heterologous expression of an engineered full length CipA from Clostridium thermocellum in Thermoanaerobacterium saccharolyticum. Biotechnol Biofuels. 2013 Mar 1;6(1):32.

Podkaminer KK, Guss AM, Trajano HL, Hogsett DA, Lynd LR. Characterization of xylan utilization and discovery of a new endoxylanase in Thermoanaerobacterium saccharolyticum through targeted gene deletions. Appl Environ Microbiol. 2012 Dec;78(23):8441-7.

Guss AM, Olson DG, Caiazza NC, Lynd LR. (2012) Dcm methylation is detrimental to plasmid transformation in Clostridium thermocellum. Biotechnol Biofuels 2012, May 6;5(1):30.

Li Y, Tschaplinski TJ, Engle NL, Hamilton CY, Rodriguez M Jr, Liao JC, Schadt CW, Guss AM, Yang Y, Graham DE. (2012) Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations. Biotechnol Biofuels. 2012;5(1):2.

Brown SD, Guss AM, Karpinets TV, Parks JM, Smolin N, Yang S, Land ML, Klingeman DM, Bhandiwad A, Rodriguez M Jr, Raman B, Shao X, Mielenz JR, Smith JC, Keller M, and Lynd LR. (2011) Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum. Proc Natl Acad Sci U S A. 108(33):13752-7.

Guss AM, Kulkarni G, Metcalf WW. (2009) Differences in hydrogenase gene expression between Methanosarcina acetivorans and Methanosarcina barkeri. J Bacteriol. 191: 2826-33.

Kulkarni G, Kridelbaugh DM, Guss AM, Metcalf WW. (2009) Hydrogen is a preferred intermediate in the energy-conserving electron transport chain of Methanosarcina barkeri. Proc Natl Acad Sci U S A.106:15915-20.

Guss AM, M Rother, JK Zhang, G Kulkarni, WW Metcalf. (2008) New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species. Archaea. 2:193-203.

 

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Contact Information

Lee Riedinger
Professor of Physics
Director

Mike Simpson
Professor of Material Sciences and Engineering
Assistant Director

Wanda Davis
Assistant to the Director
443 Greve Hall
821 Volunteer Blvd University of Tennessee
Knoxville, TN 37996
865-974-7999

Ben Allen
Coordinator & Recruiter
418 Greve Hall
821 Volunteer Blvd University of Tennessee
Knoxville, TN 37996
865-974-9374

Fax: 865-974-9482

bredesencenter@utk.edu